http://purl.org/tcl/home/man/tcl8.5/TclCmd/fconfigure.htm

See also [channel] and [open].

An important use is
  fconfigure $binaryDataFile -translation binary
to make sure the file is read as binary data.
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[LV] 2008 Feb 28

Some of the wiki pages talk about the construct

===
fconfigure $serial_port -mode "$baudRate,$plex,$bits,$polarity"
===
or some such thing. The -mode flag, used for specifying baud rate, etc.
has moved to [open] now. I don't know how one would change those values on an open descriptor...

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